Effects of a Polymerized Ultrapurified Bovine Hemoglobin Blood Substitute Administered to Ponies with Normovolemic Anemia
نویسندگان
چکیده
منابع مشابه
Successful use of a polymerized hemoglobin blood substitute in a critically anemic Jehovah's Witness.
A stable, polymerized hemoglobin product has been formulated that overcomes the three traditional hurdles of hemoglobin-based blood substitutes: nephrotoxicity, osmotic diuresis, and blood-borne pathogens. We present a case of a patient with persistent colonic bleeding and a hemoglobin of 2.9 g/100 mL. Since her religious faith prevented her from accepting blood products, we offered a hemoglobi...
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Polymerized Porcine Hemoglobin (pPolyHb), a hemoglobin-based oxygen carrier (HBOC), was developed as a potential red blood substitute for clinical applications. Assessment of its effects on the immune system is an important component of the overall safety evaluation of HBOC. For this purpose, we assessed three inflammation indicators, including complement C3a, IL-6, and TNF-? in cultured cells ...
متن کاملEffects of the molecular mass of tense-state polymerized bovine hemoglobin on blood pressure and vasoconstriction.
Despite recent advances in the design of hemoglobin (Hb)-based oxygen carriers (HBOCs), vasoconstriction, presumably caused by nitric oxide (NO) scavenging, vessel wall hyperoxygenation, and/or extravasation, has been identified as the principal road block hampering commercial development of HBOCs. This study was designed to analyze systemic and microvascular responses to the molecular mass and...
متن کاملMechanism of interference of a polymerized hemoglobin blood substitute in an alkaline phosphatase method.
BACKGROUND Hemoglobin-based oxygen carriers can cause profound interferences in many analytical procedures. We determined the mechanism of interference in the assay of alkaline phosphatase activity and identified approaches that might be used to correct for this interference. METHODS Interference of a polymerized hemoglobin blood substitute with the assay of alkaline phosphatase was examined ...
متن کاملUse of Human Polymerized Hemoglobin Solution to Augment Acute Normovolemic Hemodilution, Replace Surgical Blood Loss, and Manage Acute Postoperative Blood Loss for a Jehovah's Witness
Significant progress has been made in the development of oxygen-carrying hemoglobin solutions for therapeutic use. Religious objection to donor red blood cells in the setting of perioperative blood loss and anemia is one of several potential uses of these products. Here we present a case in which a polymerized hemoglobin solution was used on a compassionate care basis to augment acute normovole...
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ژورنال
عنوان ژورنال: Journal of Veterinary Internal Medicine
سال: 2002
ISSN: 0891-6640
DOI: 10.1892/0891-6640(2002)016<0396:eoapub>2.3.co;2